Horizontal Genetic Exchange, Evolution, and Spread of Antibiotic Resistance in Bacteria
نویسندگان
چکیده
منابع مشابه
Horizontal genetic exchange, evolution, and spread of antibiotic resistance in bacteria.
Some transformable bacteria have acquired target-mediated antibiotic resistance by horizontal genetic exchange of fragments of chromosomal genes. The resistant strains express variants of the antibiotic target that are metabolically active but exhibit a lowered affinity for the antibiotic. The alleles encoding these resistant proteins are mosaics comprising DNA derived from the host and other b...
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Antibiotic resistance thwarts the treatment of infectious diseases worldwide. Although a number of factors can be identified which contribute to the problem, clearly the antibiotic as a selective agent and the resistance gene as the vehicle of resistance are the two most important, making up a 'drug resistance equation'. Both are needed in order for a clinical problem to arise. Given sufficient...
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1Centre for Cellular and Molecular Biology, (CSIR), Hyderabad 500 007, India 2Molecular Microbiology Laboratory, Department of Biotechnology, University of North Bengal, Siliguri, West Bengal 734 430, India 3Experimental Limnology, Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB), Alte Fischerhuette 2, 16775 Stechlin, Germany 4Institute of Biochemistry and Biology, Potsdam Uni...
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Bacterial infections are becoming increasingly difficult to treat due to widespread antibiotic resistance among pathogens. This review aims to give an overview of the major horizontal transfer mechanisms and their evolution and then demonstrate the human lower gastrointestinal tract as an environment in which horizontal gene transfer of resistance determinants occurs. Finally, implications for ...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 1998
ISSN: 1058-4838,1537-6591
DOI: 10.1086/514917